In regard to the above presented controversies, a concise risk-benefit analysis in form of a rigorous conducted systematic review could greatly influence decision-making by clinicians to offer the most effective treatment to this patient population. The checklist can be found in the Additional file 1. The typical clinical sign of early skin infection with B. Clinical characteristics and treatment outcome of early Lyme disease in patients with microbiologically confirmed erythema migrans. Additionally, we will check reference lists of included studies and contact experts. The many faces of solitary and multiple erythema migrans. Therefore, we will evaluate pre-specified classes of antibiotics such as doxycycline, amoxicillin, amoxicillin plus probenecid and cephalosporins, other antibiotics and combinations of antibiotics in subgroup analyses. Efficacy and safety of pharmacological treatments for neuroborreliosis—protocol for a systematic review. Rev Med Suisse. While probenecid was used as co-administration in treatment with amoxicillin to increase bioavailability in trials conducted in the USA, probenecid is not used anymore when treating with amoxicillin.
Heidelore Hofmann of Technische Universität München, Munich TUM with München | TUM · Klinik und Poliklinik für Dermatologie und Allergologie (Am. Heidelore Hofmann of Technische Universität München, Munich (TUM) | Read 19 publications, Jan ; Fallstricke und Fehlerquellen in der Dermatologie.
Hofmann H(1). Author information: (1)Klinik für Dermatologie und Allergologie, Technische Universität München. [email protected]
For non-RCTs, we will consider both cohort and case-control studies.
Accessed 21 Mar You can move this window by clicking on the headline. While the duration of treatment of persistent symptoms attributed to borreliosis is major area of debate, there is an overall consensus in favour of antibiotic treatment but dosage and duration of treatment is still subject of debate.
Reviewers will not be blinded to study author, journal or institution. Objectives This review aims to explore differences in efficacy and safety between pharmacological treatments and compared to control treatment in adults with EM.
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Klinik und Poliklinik für Dermatologie und Allergologie. am Biederstein, Technische Universität München.
Dermatologie und Venerologie pp | Cite as Heidelore Hofmann. Heidelore Hofmann Hofmann H () Lyme Borreliosis — problems of serology.
For screening, records will be imported into the reference managing software Endnote X7 Thomson Reuters.
Systematic Reviews 5 Chapter 8: assessing risk of bias in included studies. Benefits and harms of pharmacological treatment in erythema migrans have not yet been adequately assessed. Remission of cutaneous symptoms healing rate, improvement : We acknowledge that eradication of the bacterium would be the most preferable outcome in the treatment of EM.
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Provided that the identified trials are comparable in terms of clinical issues, combined estimates will be provided. Controversy exists about the choice of drug, dose and length of treatment in the therapy of EM.